Certara is the largest and most comprehensive provider of biosimulation (modeling and simulation), strategic pharmacometrics, and regulatory writing consulting services. Our multidisciplinary team works alongside clients to inform key drug development decisions and expedite the processes around achieving regulatory milestones.
Certara combines its industry renowned pharmacometric and regulatory consultants with our vast software portfolio to provide services that focus on specific outcomes, therapeutic areas, regulatory milestones, and specific populations.
United States: 1-888-708-7444 or 1-919-852-4685
France: +33 1 56 95 17 10
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United Kingdom: +44 (0) 114 292 2322
India: +91 984 500 6625
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Muse® Invent™ is a molecular design workflow designed to accelerate the identification and optimization of lead candidates. It enables researchers to create drug candidates with novel structures, scaffolds or side-chains that are not only synthesizable, but it also describes the necessary synthesis pathway.
With Muse Invent, scientists can:
Multi Criteria Drug Design
TriposScore is an optional scoring function that can be used with Muse Invent for ligand based multi-criteria drug design. Developed in collaboration with AstraZeneca, TriposScore has been extensively validated in drug discovery projects. TriposScore uses a rigid 3D template and takes into account shape and pharmacophore similarity but also includes many more design criteria (E.g. cLogP, MW, TPSA, Lipinski Counts, Rotatable Bond Counts, etc).
Muse Invent and TriposScore can be easily integrated with ANY scoring function, allowing the user to incorporate 3rd party or in-house criteria and models (computational chemistry programs from 3rd party vendors).