Hi all,

I am going through PK 33 in Dr. Dan's book (5th version) about the transdermal input and kinetics. There are several models in the WinNonlin file, including Poisson model and Poisson model MD. I have some questions and hope someone can help me here.

1) The Poisson model is similar to the WNL5 model in the 4th version (the codes are similar). However, the results are not the exactly the same. For example, the V=253 in Poisson model while V = 336 in WNL5 model. What is the possible reason for the difference?

2) The result of another model, Poisson model MD, is almost the same as that in Dr. Dan's book (4th version). There are two dosepoints (one bio is F and the other bio is 1-F). It looks like it is similar to multiple absorption route? Furthermore, lCl and IV were used in the PML code as primary parameters (I guess that lCl is LnCl and lV is Ln since V=exp(lCl) and Cl = exp(lCl) in the secondary parameter statements). I tried to use Cl and V directly in the code, but the results were bad. Why use LnCl and LnV in this model?

Thank you and any input is appreciated!

LLLi