Hello,
I have a 2-cmpt pop PK model, and have generated the post-hoc output table by individual subject, which includes each of the thetas by ID. I also do have a corresponding eta table by ID.
My question is how do I setup my model to simulate exposures for each of the subjects in the study based on the individual post-hoc estimates for each subject. I would like to setup a fixed dose (126 mg given q3w for 6 cycles with PK simulations every 2 hours) for each of the subjects based on their (actual theta and eta) post-hoc estimates.
Previously I believe I was doing clinical trial simulations by accepting all fixed and random effects with my model, and adding a simulation table to include 50 random individuals, I added the dosing sheet, and put in seq (0,2260,2) with CObs as the output, I would then do descriptive stats on CObs and plot the median and also the shaded area band from the 5th to 95th percentiles (90% confidence). Feel free to see the image below.
This time around I am interested in the post-hoc analysis, but am not familiar with the approach for this. I would like to see the entire profiles, and generate PK parameters such as AUCtau for each actual subject ID based on the actual post-hoc theta and eta estimates (and not a random population of 50 theoretical subjects with the fixed population PK estimates as I had done before in the image above). You can see I also added the actual observations into the plot.
I imagine I will get a table (DV vs CObs) for each of the actual subject IDs, which I could then do a simple NCA with descriptive stats based on the post-hoc results.
Thanks a lot for your input, please see my model below. If you could please describe the process and also help me set this up in my model I would be much obliged.
https://www.dropbox....is.phxproj?dl=0
Edited by csheme, 01 April 2018 - 04:40 PM.