I made an attempt to generate an IVIVR based on two ER test formulations and encountered a few problems.
1) The dissolution profiles failed to fit any of the model in Phoenix
2) I tried using raw data to generate the IVIVC but failed.
Please assist? The drug is poorly absorbed with BA of ~ 7%
Oral data was obtained as 60 mg but i normalized the dose to 180 mg (the ER is 180 mg).
Is it possible to generate some sort of correlation?
P.S. Sorry I made a typo on the dataset names. the in-vitro is actually the in-vivo data and the in-vivo is the in-vitro data.
Edited by John CK Lai, 12 December 2018 - 04:28 PM.