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Need some help (IVIVC w mean Data)


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#1 John CK Lai

John CK Lai

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Posted 12 December 2018 - 04:03 PM

Hi,

 

I made an attempt to generate an IVIVR based on two ER test formulations  and encountered a few problems.

1) The dissolution profiles failed to fit any of the model in Phoenix

2) I tried using raw data to generate the IVIVC but failed. 

 

Please assist?  The drug is poorly absorbed with BA of ~ 7%

Oral data was obtained as 60 mg but i normalized the dose to 180 mg (the ER is 180 mg).

Is it possible to generate some sort of correlation?

 

Thank you.

John

 

P.S.  Sorry I made a typo on the dataset names.  the in-vitro is actually the in-vivo data and the in-vivo is the in-vitro data. 

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Edited by John CK Lai, 12 December 2018 - 04:28 PM.


#2 Simon Davis

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Posted 12 December 2018 - 04:30 PM

Hi John,  the project posted is just the data, do you have a project where you have the workflow set up? to save people a little time in replicating your work and see what you'd already done.

 

 Simon.



#3 John CK Lai

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Posted 12 December 2018 - 04:47 PM

Hi John,  the project posted is just the data, do you have a project where you have the workflow set up? to save people a little time in replicating your work and see what you'd already done.

 

 Simon.

Thanks Simon.  I will set it up and repost.

 

John






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