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NLME Posthoc


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#1 csheme

csheme

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Posted 27 April 2019 - 03:00 AM

Hi,

I have an established popPK model, how do I get the post hoc exposure estimates for Cmax, Cmin, and AUC of each subject in the model. Thanks

#2 Simon Davis

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Posted 27 April 2019 - 06:05 AM

Hi Colby, If you are using  a built in model then you can probably easily get these secondary parameters by using the SET WNL model option; if you haven't seen this before then check the manual or look at https://support.cert...dary-parameters

 

if you need AUC from any differential equation model then you can use

deriv(myAUC = C)

and then including it in a table,  as has been discussed in previous posts; https://support.cert...ml-model/?p=614

 

or Cmax here...

 

https://support.cert...-in-compartment

 

and you can also find time above a threshold; https://support.cert...above-threshold

 

alternatively you could calculate them after using a data wizard, other data tools eg desc. stats if you request a fine enough grid in a table statement.

 

https://support.cert.../topic/740-aucf

  Simon.






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