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Allometric scaling animal to human


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#1 harishkaushik



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Posted 03 June 2019 - 09:39 AM


I have preclinical PK data from 4 species (Mice,Rat,GuineaPig & Dog)

i wanted to utilise the phoenix automation for predicting FIH dose and profile, I viewed the webinar by Serge it was helpful, but is there any way that i can use that code/ phoenix automation for my purpose




#2 Simon Davis

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Posted 05 June 2019 - 09:48 AM

Hi Harish, Serge's video was a proof of concept template he made,  let me look around and see what I can find to help you; in the mean time these links maybe useful.  This recorded lesson shows an example of implementing allometric scaling in Phoenix, and also has a text model example file:




you  could try modifying the text model file provided there, use it with your own data, and post any questions or issues with that model to this thread.  Don't forget to read the Q and A too.





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