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incremental AUC

drug effect AUCi net AUCi

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#1 Graham Blakey

Graham Blakey

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Posted 28 October 2019 - 05:59 PM

I am working with a dietary supplement that increases the systemic amount of several amino acids (aa) above baseline values.  The analysis requires estimation of incremental AUC (AUCi)  and net incremental AUC (net AUCi).  I have a baseline value for the aa only, there is no threshold value.  The drug effect (model 220) option in NCA allows the input of a baseline value and provides as output the parameters outlined below

 

 

Is AUC Above B  equivalent to AUCi? Can net AUCi be estimated as

[AUCabove  B] - [AUC below B]? See Figure 11 (c & e) in the attached paper discussing glycemic index for reference of what I am looking to estimate.

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Edited by Graham Blakey, 28 October 2019 - 06:02 PM.


#2 bwendt@certara.com

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Posted 29 October 2019 - 10:43 AM

Graham,

 

the drug effect model in NCA calculates 3 values: 

 

AUCnet.png

 

Here:

AUC_Above_B accumulates all areas that are above the baseline, excluding  any areas below the baseline

AUC_Below_B accumulates all areas that are below the baseline, excluding any areas above the baseline.

AUC_Net_B calculates the difference between these two values.

According to figures 11 c & e:

the black areas in figure 11 c)  represents AUC_Above_B,

the white area between the two black areas in figure 11 c) represents AUC_Below_B

and figure 11 e) represents AUC_Net_B.

 

Hope, this makes sense. Let me know if there are further questions.

 

Bernd



#3 Graham Blakey

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Posted 31 October 2019 - 05:08 PM

Excellent, Thanks Bernd for the clarification






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