I am working with a dietary supplement that increases the systemic amount of several amino acids (aa) above baseline values. The analysis requires estimation of incremental AUC (AUCi) and net incremental AUC (net AUCi). I have a baseline value for the aa only, there is no threshold value. The drug effect (model 220) option in NCA allows the input of a baseline value and provides as output the parameters outlined below
Is AUC Above B equivalent to AUCi? Can net AUCi be estimated as
[AUCabove B] - [AUC below B]? See Figure 11 (c & e) in the attached paper discussing glycemic index for reference of what I am looking to estimate.
Edited by Graham Blakey, 28 October 2019 - 06:02 PM.