I have included a minimal example file of the problem I'm having fitting a PKPD dataset with resets.
I fit a two compartment population PK model with random effects on V and CL. I copied this model to run sequential population PKPD. I linked the Eta from my PK model to the Random Effects in my PKPD model. Initial estimates are functioning normally and look good, but when I run the fit, my resets are not recognized and each animal is given a sum of all the doses.
Am I doing something wrong, or is this a bug? If so does anyone have a workaround? Thanks!
Attached Files
Edited by cphipps, 16 May 2020 - 02:44 PM.