2 replies to this topic

[sirikalyan]

Hi,

I want to use Phoenix for performing Average Bioequivalence (ABE) of a 2x2x2 design using the GLM model proposed by FDA in their guidance.

While I can use subject as a random effect, in Phoenix and perform ABE, this would become mixed effect model.

 

Can you please let me know how to use subject nested in sequence as a fixed effect while using phoenix.

 

[Simon Davis]

Delete Subject(Seq) from random tab.

 

And add it to the end of Fixed Effects.

 

Remember it is case sensitive.

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Edited by Simon Davis, 26 June 2020 - 05:45 AM.

[Simon Davis]

Phoenix uses the same algorithm with or without random effects.
- it is like PROC MIXED, whether there are random effects or not.

Simon.

edit: actually to clarify if all effects are fixed then GLM is feasible
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For the case when subject only is random and the design is not replicated it is still GLM, you may read a more detailed discussion on this thread https://forum.bebac....id=19512#p19524

Edited by Simon Davis, 15 July 2020 - 12:30 PM.