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Linear Mixed Effects Model Estimates

Linear Mixed Effects Model Phoenix WinNonlin

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#1 littlepetinga

littlepetinga

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Posted 06 April 2021 - 11:49 AM

Hello All,

 

I am using Phoenix WinNonlin 8.2 Linear Mixed Effects Model tool to identify differences between a Treatment and Placebo.

 

On the Final Fixed Parameters output, I noticed that the program is calculating the estimate,  CI and p-value for Placebo, and that for Treatment those appear as 'Not estimable'.

 

I ask if it's possible to define the variable (e.g., Treatment instead of Placebo) for which the program will calculate the estimates.

 

Thank you in advance

Sara 



#2 bwendt@certara.com

bwendt@certara.com

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Posted 14 April 2021 - 08:39 AM

Dear Sara,

 

in principal, you have an input with a column where you specify your Treatment:

 

Trt.png

 

You would then use this column (Treatment) as variable in your model specification:

 

linmix.png

 

Please refer to our LinMix example that you find in your Phoenix installation.

 

Bernd

 

Attached Thumbnails

  • linmix_res.png





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