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Intrinsic clearance (CLint)

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#1 madushadrack



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Posted 20 August 2021 - 10:08 AM

I am working on developing a PBPK model for a drug metabolised by phospholipase D. Scanty information is available with respect to the drug.


I only have the value of the Clearance (CL/F) (liters/day). How can I go about calculating intrinsic clearance of the drug as the km and vmax are not known.



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