Dear Certara Team,
We are using the IVIVC Toolkit to perform IVIVC for a sustained release injectable microparticle system administered subcutaneously.
In the deconvolution step (vivo tab), we are applying the following settings (Attachment 1).
As a UIR, we are using IV infusion data, attached is the graph Y obs. vs Y pred. (Attachment 2), that looks like they correlate nicely.
When our in vivo data are deconvolved, we get the following prediction profile (plasma conc vs time - Attachment 3), where it appears that the deconvolution calculations do not describe well the initial burst peak.
Could you please advise us whether we have got something wrong in the set-up or whether there might be a way to improve our prediction profile?
Any input would be very much appreciated! Please let us know if we can provide more info.
Looking forward to hearing back.