Jump to content


Photo

SC Implant


  • Please log in to reply
3 replies to this topic

#1 Susan

Susan

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 22 July 2022 - 09:16 PM

Is it feasible to use the IVIVC module to predict in vivo exposure from a SC implant, when the in vivo PK is flat (non-standard)?  The objective is to estimate in vivo exposure based on in vitro dissolution, but there is not a clear Cmax/Tmax/absorption phase, regardless of the implant formulation.



#2 Simon Davis

Simon Davis

    Advanced Member

  • Administrators
  • 1,233 posts

Posted 26 July 2022 - 06:43 AM

can you perhaps post some plots of your data, how long is  absorption 'flat' for?  DO you get to see clearance kick in at all in the in vivo data?



#3 Susan

Susan

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 26 July 2022 - 03:18 PM

Happy to share a graph to demonstrate.  The attachment shows a graph of in vivo exposures over 182 days, and in vitro dissolution over 150 days.

 

 

 

Attached Thumbnails

  • buist.jpg

Edited by Simon Davis, 02 August 2022 - 08:13 AM.


#4 cradhakr

cradhakr

    Advanced Member

  • Members
  • PipPipPip
  • 55 posts

Posted 01 August 2022 - 11:40 PM

Hi Susan,

 

If you cant share details in the forum you could send the information to - support@certara.com

 

Thanks

Mouli






0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users