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PK-PD model of Binary repsonse

modeling simulation binary

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#1 Ygsla

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Posted 01 August 2022 - 05:01 AM

HI Folks,

 

Can we develop PK-PD model with binary reponse data in NLME? 

 

If yes, sharing some more information or suggestion or any built template will be appreciated.

 

 

Thanks in advance!!

 

Regards,

Ygs



#2 Simon Davis

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Posted 01 August 2022 - 07:11 AM

Hi Ygs, there are some worked examples listed inthe help;

https://onlinehelp.c...imum_Likelihood

 

e.g. Three category multinomial model with a covariate

Simon



#3 bwendt@certara.com

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Posted 01 August 2022 - 08:48 AM

Hi Yglsla,

 

there are also a couple of examples in out PML School (NONMEM-NLME Comparisons):

 

https://support.cert...rical-response/

 

Bernd



#4 Ygsla

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Posted 01 August 2022 - 10:16 AM

Thank you Simon and Bernd for information and suggestions.

 

Thanks.. :)  

 

Regards,

Ygs 



#5 smouksassi1

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Posted 10 August 2022 - 08:01 AM

note that phoenix has lot of flexibility and you have multi, ordinal :

https://onlinehelp.c...rdinal&rhsyns=

 

binary 0/1 is a special case of more general 0/1/2,... models

 

when using multi or ordinal you will have automatic simulation and vpc

 

 

you can also write your LL + simulate statement to do whatever you need






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