2 replies to this topic

[mjPK]

Hi 

 

I am working on a multi-compartment model and I have been using the two-way micro-parameter formulation with a K_in and K_out.

 

Ideally I would like to formulate the model where I can fit a Volume, K_in and K_out. That does not seem possible out the box it seems. I know there is the Cl/V fitting where you can check a two way clearance but I do like the explicit K values in both directions. 

 

I have two questions

 

1) is there a way to recover the volume value from the two-way microparameter setup?

 

2) is there a way to change my parameters to be mixed say Volume and K_in or something along those lines 

 

Thanks in advance 

[Simon Davis]

Regarding V – I am not sure I understand your problem, it is presented in micro parameterization, if you want V2 then you can go to graphical mode and check the conc box but I imagine you will have identifiability issues.

 

if you need a parameter that is not output already in theta tables then you can request on the Run options tab with a new table by clicking Structural parameters or specifying explicitly.

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[mjPK]

Regarding V – I am not sure I understand your problem, it is presented in micro parameterization, if you want V2 then you can go to graphical mode and check the conc box but I imagine you will have identifiability issues.

 

if you need a parameter that is not output already in theta tables then you can request on the Run options tab with a new table by clicking Structural parameters or specifying explicitly.

 

 

Thanks for the reply. I found a pathway to what I wanted via the PML school by adding a fixed effect term in the code. I was looking for a way to do this graphically. I will try the add table thing you mentioned here. 

 

Thanks!