2 replies to this topic

[peggy.lin@effpha.com]

Hi all,

 

I have rat PK data for 4 formulations. One of the formulation (group 2) is the fast-releasing patch. I used the mean concentration from group 2 animals for PK modeling. I ran the model (entitled "ML Model_Ref_Ind_multi_Text") with good fitting and diagnostic plot and the return code of 1.  However, in the Theta page, there is a lack of CV% and related statistics info.

 

Would it be a problem? Could anyone please help to find out the reason for this? 

 

The phoenix project is attached. 

The patch contains diclofenac, therefore, I use the 3-cmpt model as the same with the reference for diclofenac IV bolus administration(Ref. Willies 1979); the absorption compartent is skin, which is reference from another PK modleing for other patch (Ref. Nozaki 2016).

 

 

Looking forward for your suggestions.

 

 

Peggy

 

 

Attached Files

•  rat PK_20241008_test.phxproj   7.39MB   16 downloads
•  Nozaki-2016-PK modeling to simulate the concentration-time profiles after dermal application of rivastigmine patch.pdf   2.03MB   16 downloads
•  willis1979_iv diclofenac 3 cmpt PK in female subject.pdf   637.84KB   20 downloads

[David]

 

 

Hi,

Please try change method:

Run option---method: select "sandwich"

 

DV

Edited by Simon Davis, 10 October 2024 - 11:46 AM.
just shortening the repost

[David]

Hi,

Please try change method:

Run option---method: select "sandwich"

 

DV