I am wondering the correct way to simulate different oral dosing regimens given just IV bolus data plus structural model. Is there somewhere we input bioavailability? I guess this wouldn't matter if all parameters are expressed without the "F" term?
Also, why does st error and CV% keep disappearing on THETA tab after executing the poppk analysis several times? I'm guessing it has to do with me updating the initial estimates tab.. [file name=QuinidineNov2012.phxproj size=5576396]http://pharsight.com/extranet/media/kunena/attachments/legacy/files/QuinidineNov2012.phxproj[/file]