I've set up a simple oral two-compartment model (attached). Central compartment is plasma concentrations and peripheral compartment is tumour concentrations. I can't get the model to fit both data sets (same profile for both data sets)?
By the way, this model nicely fitted the data using some old software (TOPFIT).
Charlie [file name=BGN_tumour.phxproj size=361704]http://www.pharsight.com/extranet/media/kunena/attachments/legacy/files/BGN_tumour.phxproj[/file]