Hi all,
is it possible to apply weighting shemes when running a Phoenix model? Like the option 1/Yhat or 1/Yhat^2 in the WinNonlin classic platform.
thanks,
Chris
Posted 03 February 2016 - 03:55 PM
Hi Chris, the simple weighting used in the WNL classic engine to account for residual error is now handled as Eps (epsilon) and to get started you can consider that;
Additive is uniform in classical WinNonlin (Cpred + eps)
Multiplicative is 1/Yhat*Yhat in WNL (Cpred + Cpred*eps)
Power is (Yhat)-2a (Cpred + Cpreda*eps)
This has been discussed a few times so using the search function could give you some more examples.
e.g. http://www.certara.c...l/?hl=weighting
and http://www.certara.c...ghting#entry121
among others.
Simon
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