1 reply to this topic

[cbundgaard]

Hi all,

is it possible to apply weighting shemes when running a Phoenix model? Like the option 1/Yhat or 1/Yhat^2 in the WinNonlin classic platform.

thanks,

Chris

[Simon Davis]

Hi Chris, the simple weighting used in the WNL classic engine to account for residual error is now handled as Eps (epsilon) and to get started you can consider that;

Additive is uniform in classical WinNonlin (Cpred + eps)
Multiplicative is 1/Yhat*Yhat in WNL (Cpred + Cpred*eps)
Power is (Yhat)-2a (Cpred + Cpreda*eps)

 

This has been discussed a few times so using the search function could give you some more examples.

 

e.g. http://www.certara.c...l/?hl=weighting

 

and  http://www.certara.c...ghting#entry121

 

 among others.

 

 Simon

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