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PK turnover model

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#1 LLLi

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Posted 09 September 2016 - 07:30 PM

Hi,

 

I am studying the turnover of proteins, peptides and antibodies (Dr. Dan Weiner's textbook). There is an application about  the turnover of hormone (PK30). A volunteer received a 40 ug/kg dose D of IgX (sc). The IgX concentrations were measured before and after the dose. WNL5 ASCII format was used to calculation PK parameters (V, ka, turn-over rate and Cl etc). Please see the attachment.

 

I am wondering if there is any other method to do PK turnover model besides WNL5 ASCII format. I tried Indirect response model (IR) and PKPD model. But it seems that these two models are for PD data.

 

Thank you!

 

LLLi

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#2 serge guzy

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Posted 14 September 2016 - 08:45 AM

Here we go. The project has been translated into Phoenix.

Let me know if you need further explanations. We need to write the code for this case.

Best Regards

Serge

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#3 Simon Davis

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Posted 03 October 2016 - 09:10 AM

LLLi, you may also wish to join the webinar this Thrusday and *follow* this new sub-forum;

 

https://support.cert.../34-pml-school/

 

 It is dedicated to teaching people the use of the Phoenix modelling language as it is more versatile and powerful than the old ASCII code and engine.

 

  Simon



#4 LLLi

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Posted 16 November 2016 - 10:28 PM

Hi All,

 

I wanted to transfer ASCII code into PML but failed. Would you please help me to figure it out? Please see the details in the project attached.

 

Background: iv of hormone (so it is a turnover model); infusion time = 0.0167 hr; infusion dose = 36630.

 

Thank you very much!

LLLi

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#5 serge guzy

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Posted 17 November 2016 - 03:55 AM

Dear LLi

You had few coding errors.

First the if condition in the main code is not as you wrote. I fixed it.

Second you did not write the right initial condition for C2. I fixed it.

Let me know if the results look good  to you now.

the updated project is attached.

best Regards

Serge

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#6 LLLi

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Posted 17 November 2016 - 04:07 PM

Here we go. The project has been translated into Phoenix.

Let me know if you need further explanations. We need to write the code for this case.

Best Regards

Serge

Hi Serge,

Why you freeze Tlag=0 in your project (the first project that you posted)?

I removed the freeze in the code and Tlag is less than 0.

Thank you!

LLLi


Edited by LLLi, 17 November 2016 - 04:11 PM.


#7 LLLi

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Posted 17 November 2016 - 08:59 PM

Dear LLi

You had few coding errors.

First the if condition in the main code is not as you wrote. I fixed it.

Second you did not write the right initial condition for C2. I fixed it.

Let me know if the results look good  to you now.

the updated project is attached.

best Regards

Serge

Hi Serge,

 

Thank you for your reply.

 

I have another question about the if condition. 

In my project, The format is In=(t<=t2?A:C)

If the condition is more complex, for example:

if t<t1, In=A, if t1<t<t2, In=B, if t>t2, In=C.

How to write this if statement in the code?

 

Furthermore, in turnover model, the deriv(C=) contains "In" while in the other model, there is no In in deriv(A=). Why?

 

Thank you!

LLLi


Edited by LLLi, 17 November 2016 - 09:36 PM.


#8 serge guzy

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Posted 18 November 2016 - 10:07 AM

Hi Serge,

Why you freeze Tlag=0 in your project (the first project that you posted)?

I removed the freeze in the code and Tlag is less than 0.

Thank you!

LLLi

I am not sure about the project you are talking about. Can you send it to me?



#9 serge guzy

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Posted 18 November 2016 - 10:11 AM

Hi Serge,

 

Thank you for your reply.

 

I have another question about the if condition. 

In my project, The format is In=(t<=t2?A:C)

If the condition is more complex, for example:

if t<t1, In=A, if t1<t<t2, In=B, if t>t2, In=C.

How to write this if statement in the code?

 

Furthermore, in turnover model, the deriv(C=) contains "In" while in the other model, there is no In in deriv(A=). Why?

 

Thank you!

LLLi

 

In that case you would write

ln=(t<t1?A:t<t2?B:t>t2?C)

 

about the next question I just translated the model you gave me. I am not sure it that question related to what I fixed.

Best

SERGE



#10 LLLi

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Posted 18 November 2016 - 02:31 PM

I am not sure about the project you are talking about. Can you send it to me?

Hi Serge,

 

Thank you for your reply!

 

Sorry for the confusion. The project was uploaded by you in this post (PK30 turnover model sc dosing.phxproj). Here I uploaded it for your reference.

 

Thank you!

LLLi

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