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Choose different residual error structure

residual error

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#1 LLLi

LLLi

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Posted 13 October 2016 - 02:49 PM

Hi all,

 

I fitted a 2 compartment model to a set of data (only one subject) using different residual error structures. Please see the phoenix project attached.

 

I compared the Ind DV vs IPRED; lnd DV, IPRED vs IVAR (y is logarithmic scale); lnd IWRES vs IPRED; and Ind IWRES vs IVAR. I also gave a score to each structure for each figure (score 1 means the best, score 3 means the worst). Please see the excel attached. Which residual error structure is the best one?

 

Thank you!

 

LLLi

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#2 Simon Davis

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Posted 13 October 2016 - 03:28 PM

I would personally go with mixed, it has the lowest AIC of the 3 models and generally the best residual plots.

 

I suggest you take another look at Ind IWRES vs IPRED, since for mixed there are no points outside the 2 sd lines and generally are closer to the centre line than additive or indeed multiplicatve alone

 

  Simon







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