Here is a contribution from Johan Gabrielsson to our recent webinar on TMDD:
He just published a paper in the AAPS Journal on TMDD models where he showed how to apply acute dose disposition data/information to predict the target suppression vs ligand (R vs L), complex versus ligand (RL vs L) and ligand concentration at half-maximal R0 and RLmax (L50).
If you are interested, please download a copy of the article:
Gabrielsson_et_al-2017-The_AAPS_Journal.pdf 1.11MB
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Bernd
