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How to build PK-PD model for oral delivery


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#1 venky5019

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Posted 21 March 2019 - 02:18 PM

I am having plasma concentration data for oral all the tissue concentration also. I have the values for dynamic effect also. Please suggest me how to build a PK-PD model for the same.



#2 venky5019

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Posted 21 March 2019 - 02:21 PM

Please attach a template for the same.

Looking forward to hear.



#3 Simon Davis

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Posted 21 March 2019 - 02:34 PM

Hi Venky please do not expect people to do your work for you.

 

  As I mentioned already to you privately, in the NLME examples guide there is a worked example of IV and oral data as well as how to use the graphical model further so you could add an Emax or other PD model.  The type of model required will depend on your data so please try to work up your example first and then you can post your code/project to ask people for comments/tips.

 

  Other resources are of course existing posts on this forum;

 

https://support.cert...al-and-iv-data/

 

https://support.cert...ingle-equation/

 

https://support.cert...o-2-cpmt-model/

 

  Or you could undertake some training;  there is a course next month in Bangalore;

 

Introduction to Phoenix WinNonlin + IVIVC toolkit, Bengaluru, India, 2-4 April 2019

 http://www.certarauniversity.com/lms/

 

or there is online training that can be taken over up to 3 years;

 

https://www.certarau...oenix-winnonlin

 

I imagine you model might start something like the attached, that takes a couple of minutes to edit from a base model 1 com extravascular model.

 

  Simon.

Attached Thumbnails

  • Cp_Ct_E.jpg


#4 venky5019

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Posted 22 March 2019 - 01:04 PM

Hi Venky please do not expect people to do your work for you.

 

  As I mentioned already to you privately, in the NLME examples guide there is a worked example of IV and oral data as well as how to use the graphical model further so you could add an Emax or other PD model.  The type of model required will depend on your data so please try to work up your example first and then you can post your code/project to ask people for comments/tips.

 

  Other resources are of course existing posts on this forum;

 

https://support.cert...al-and-iv-data/

 

https://support.cert...ingle-equation/

 

https://support.cert...o-2-cpmt-model/

 

  Or you could undertake some training;  there is a course next month in Bangalore;

 

Introduction to Phoenix WinNonlin + IVIVC toolkit, Bengaluru, India, 2-4 April 2019

 http://www.certarauniversity.com/lms/

 

or there is online training that can be taken over up to 3 years;

 

https://www.certarau...oenix-winnonlin

 

I imagine you model might start something like the attached, that takes a couple of minutes to edit from a base model 1 com extravascular model.

 

  Simon.

Dear Sir,

 

I have tried to analyse data as per your suggested attachment model. 

I prepared a model according, but in the main tab i.e, Mappings I was unable to see the Concentration of tissue observed input to select my data.

Please see the below attachments for the same and kindly suggest to how to carry on further to analyse my data.

Attached Thumbnails

  • model.jpg
  • model1.jpg


#5 Simon Davis

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Posted 22 March 2019 - 01:22 PM

Venky, you're close.  You just need to insert another contiunous observation (right-click in the white space)

then you can drag the bottom right node of the Tissue compartment  to link to this and ensure you label the observation and it's error consistently so there are no syntax conflicts.

 

if you can't do it still please, post the project and I can link it for you.

 SImon.


Edited by Simon Davis, 22 March 2019 - 01:26 PM.


#6 venky5019

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Posted 22 March 2019 - 01:44 PM

Venky, you're close.  You just need to insert another contiunous observation (right-click in the white space)

then you can drag the bottom right node of the Tissue compartment  to link to this and ensure you label the observation and it's error consistently so there are no syntax conflicts.

 

if you can't do it still please, post the project and I can link it for you.

 SImon.

Dear Sir,

 

I have tried as per your suggestion, but still i am unable to proceed. Please find the below attachment and kindly suggest me to proceed further.

 

Thank you very much sir.

Attached Files



#7 Simon Davis

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Posted 22 March 2019 - 04:48 PM

please find the completed project and steps in the word doc, However looking at your data I don’t think you necessarily have 2 com kinetics for your plasma conc so you may have to re-think your approach.

 

 Simon

Attached Files


Edited by Simon Davis, 22 March 2019 - 04:49 PM.


#8 venky5019

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Posted 22 March 2019 - 04:56 PM

please find the completed project and steps in the word doc, However looking at your data I don’t think you necessarily have 2 com kinetics for your plasma conc so you may have to re-think your approach.

 

 Simon

Dear Sir,

 

Thank you very much for ur valuable suggestions.






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