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Combined zero and first-order absorption with Tlag


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#1 amashehri

amashehri

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Posted 10 January 2021 - 09:17 AM

Is it applicable to use combined zero and first-Order absorption with Tlag ? 

 

I tried to use the PML and graphical function to come up with following code 

 

cfMicro(A1, Cl / V, Cl2 / V, Cl2 / V2, first = (Aa = Ka))
dosepoint(Aa, tlag = Tlag,duration = Tabs ) 
C = A1 / V
 
I am not sure if I got it right 
 
Thanks 
 
 

 



#2 cradhakr

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Posted 10 January 2021 - 10:56 AM

Hi amashehri,

 

Yes you can do Zero order and First order input; please refer to our PML Lesson 8 (link below). 

 

 

Lesson 8: One-compartment 1st and 0-order input - PML School - Certara Forums

 

 

Our session on February 2nd dealt with absorption where we discriminated between zero-order and first-order inputs for a one-compartment model.

We have also demonstrated how to setup a multiple dose simulation with both regular and variable dosing regimens.

 

Thanks

 

Chandramouli


Edited by cradhakr, 10 January 2021 - 10:57 AM.





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