3 replies to this topic

[dg088]

Hi all,

Is there a way to create user-defined parameters based upon standard output parameters in NCA?
For example, if I want to output relative bioavailability based on two AUCs and two dosing periods in a crossover study, I have profiled the data so that for a given subject, I have AUC and dose for each dosing period. Is there a way to use those to create a user-defined output parameter F that uses that information? Or do I just need to post process this outside of Winnonlin?

Edited by dg088, 03 November 2022 - 07:43 PM.

[Simon Davis]

Hi Drew,

   Yes there is a specific object under the "Computation Tools" menu to make this part of your workflow within Phoenix that was added in 8.1.This is demonstrated here;  https://youtu.be/SoCNDwFGJ7U?t=609

 

And in the free course [114-FL] What is New in Phoenix WinNonlin 8.1

 

(the most recent version's course is here;

[125-FL] What is New in Phoenix 8.3 - Certara University

 

Prior to 8.1 it was also pretty straightforward to do this with the existing data tools as discussed here;

 

https://support.cert...ers-egauc/?p=66

 

   SImon

[dg088]

Thanks. Quick follow up to this: if I want to also include the doses, so that F = AUC1/AUC2*dose1/dose2, can this also be done using the ratio tool? Also, how to map results back to main parameter pivoted output table?

[Simon Davis]

You can carry all the required final parameters through the ratios tool, you should be able to use the doses too.