3 replies to this topic

[phoebe]

Take a 7-day dosing cycle for three times, and conduct sampling and testing in the first and third cycles. Can NCA be used for calculation?

 

Thank you~

[Simon Davis]

Most likely yes, I would analyse first profile day as naive dose and then I assume by  your third cycle you would be at SS and could then use tau in dosing panel to indicate that.

Is that the plan of your design? what is your anticipated half-life?

 

 Simon.

(Ensure your dosing interval is consistent/always equal to use NCA SS option.)

[phoebe]

Most likely yes, I would analyse first profile day as naive dose and then I assume by  your third cycle you would be at SS and could then use tau in dosing panel to indicate that.

Is that the plan of your design? what is your anticipated half-life?
 
 Simon.

(Ensure your dosing interval is consistent/always equal to use NCA SS option.)

Sorry, I am a beginner, do not quite understand what you said about NCA SS.My dosing interval is consistent.

 

My sample collection scheme is as follows:  worksheet1.xlsx   15.77KB   186 downloads

 

Please check it for me,thank you.

 

[Simon Davis]

From you sample schedule, yes NCA looks feasible, if you get stuck later when performing your NCA, then drop us a line here - (or if confidential, please email support@certara.com)