Jump to content


Photo

How to calculate pharmacokinetic parameters

NCA

  • Please log in to reply
3 replies to this topic

#1 phoebe

phoebe

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 19 February 2023 - 12:55 PM

Take a 7-day dosing cycle for three times, and conduct sampling and testing in the first and third cycles. Can NCA be used for calculation?

 

Thank you~


  • AlexKawn likes this

#2 Simon Davis

Simon Davis

    Advanced Member

  • Administrators
  • 1,331 posts

Posted 19 February 2023 - 07:06 PM

Most likely yes, I would analyse first profile day as naive dose and then I assume by  your third cycle you would be at SS and could then use tau in dosing panel to indicate that.

Is that the plan of your design? what is your anticipated half-life?

 

 Simon.

(Ensure your dosing interval is consistent/always equal to use NCA SS option.)



#3 phoebe

phoebe

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 20 February 2023 - 01:47 AM

Most likely yes, I would analyse first profile day as naive dose and then I assume by  your third cycle you would be at SS and could then use tau in dosing panel to indicate that.

Is that the plan of your design? what is your anticipated half-life?
 
 Simon.

(Ensure your dosing interval is consistent/always equal to use NCA SS option.)

Sorry, I am a beginner, do not quite understand what you said about NCA SS.My dosing interval is consistent.

 

My sample collection scheme is as follows:Attached File  worksheet1.xlsx   15.77KB   192 downloads

 

Please check it for me,thank you.

 



#4 Simon Davis

Simon Davis

    Advanced Member

  • Administrators
  • 1,331 posts

Posted 20 February 2023 - 06:58 PM

From you sample schedule, yes NCA looks feasible, if you get stuck later when performing your NCA, then drop us a line here - (or if confidential, please email support@certara.com)







Also tagged with one or more of these keywords: NCA

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users