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[abpkpd]

I am simulating multiple dose 2 Comp PK Profile for short IV infusions using WinNonlin 7. I noticed that PK Profile changes based on # Points used in simulation. For 1-2000 hr (X axis) comparing 100 vs 2000 # point (6 doses), # 100 showed variable Cmax values between different cycles where as # 2000 appeared to be consistent. I guess this can happen because of large DT. So is there a way to decide appropriate # points based on time scale or dosing regimen?