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Sparce sampling - degrees of freedom for Cmax and AUC

NCA sparse sampling Cmax AUC SE parametric test degrees of freedom

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#1 AlexKazarov



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Posted 08 July 2021 - 03:41 PM

We’ve made a single dose PK study, parallel design with 2 groups, and with sparse sampling. I performed NCA calculation on WinNonlin and received Cmax and AUClast estimation with their SE values (standard error of mean, isn’t it?)

Then, I have to perform between-group comparison of each parameter (Cmax and AUClast), with Student t-test, using third-party software. What df (degrees of freedom) should I use for Cmax and AUC? In other words, what should be my “n” in t-value formula?


And, similarly, but in case of 3 or more groups, with 1-way ANOVA instead of Student t-test – what df should I use?

Edited by AlexKazarov, 08 July 2021 - 03:42 PM.

Also tagged with one or more of these keywords: NCA, sparse sampling, Cmax, AUC, SE, parametric test, degrees of freedom

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