Dear Team,
I am with concentration data which has "2" Cmax. I would like to estimate both from concentration data profile. How Winnonlin can help me? With NCA setup do we have any option to do so?
Posted 21 February 2023 - 08:33 AM
Hi,
Cmax is defined as maximum concentration of a single profile in NCA. I take it that you have multiple peaks in your profile and you want to know at which times these are occuring and at which concentrations. This can only be done through compartmental modeling. Unfortunately, it can only be achieved through textual models. If you can share your data we can advise how to setup the model.
Bernd
Posted 21 February 2023 - 02:41 PM
As Bernd says you cna't do this directly in NCA but you may also tabulate these 'duplicate' Cmaxs by using an inner join back to the original concentration sheet a bit like here partial AUCs (PHX6.4+) - Phoenix WNL basics - Certara Forums
if you're still stuck you can post an example project so we can try to help you the last bit. Simon.
Posted 21 February 2023 - 06:48 PM
Dear Team,
I am with concentration data which has "2" Cmax. I would like to estimate both from concentration data profile. How Winnonlin can help me? With NCA setup do we have any option to do so?
Hello,
If you are just interested in the observed second peak Cmax, you could merge the data, remove the highest concentration and run an NCA again. See attached project.
Ana Henry
Certara University
Edited by Ana Henry, 21 February 2023 - 06:49 PM.
Certara Forums →
Modelling and Simulation →
Lack of CV% in Theta pageStarted by peggy.lin@effpha.com , 09 Oct 2024 Modeling, PK, Theta |
|
|
||
Certara Forums →
Phoenix WNL basics →
% AUC extrap not populate in Pivot formStarted by nileshg , 18 Dec 2023 NCA, Pivot data |
|
|
||
Certara Forums →
Phoenix WNL basics →
NCA Results PlotsStarted by BEQool , 25 Aug 2023 NCA, Plots, Plot, Number of plots |
|
|
||
Certara Forums →
Phoenix WNL basics →
NCA Multiple Dose with Different Dosing Interval - Feasible within WNL?Started by aramisrojas_ , 03 Aug 2023 NCA, multiple dose and 6 more... |
|
|
||
Certara Forums →
Phoenix WNL basics →
How to calculate pharmacokinetic parametersStarted by phoebe , 19 Feb 2023 NCA |
|
|
0 members, 0 guests, 0 anonymous users