4 replies to this topic

[d_nil]

Dear Team,

 

 

I am with concentration data which has "2" Cmax. I would like to estimate both from concentration data profile. How Winnonlin can help me? With NCA setup do we have any option to do so?

[bwendt@certara.com]

Hi,

 

Cmax is defined as maximum concentration of a single profile in NCA. I take it that you have multiple peaks in your profile and you want to know at which times these are occuring and at which concentrations. This can only be done through compartmental modeling. Unfortunately, it can only be achieved through textual models. If you can share your data we can advise how to setup the model.

 

Bernd

 

[Simon Davis]

As Bernd says you cna't do this directly in NCA but you may also tabulate these 'duplicate' Cmaxs by using an inner join back to the original concentration sheet a bit like here partial AUCs (PHX6.4+) - Phoenix WNL basics - Certara Forums

 

if you're still stuck you can post an example project so we can try to help you the last bit.  Simon.

[Ana Henry]

Dear Team,

 

 

I am with concentration data which has "2" Cmax. I would like to estimate both from concentration data profile. How Winnonlin can help me? With NCA setup do we have any option to do so?

Hello,

If you are just interested in the observed second peak Cmax, you could merge the data, remove the highest concentration and run an NCA again.  See attached project.

 

Ana Henry

Certara University

Attached Files

•  2Cmax.phxproj   850.49KB   109 downloads

Edited by Ana Henry, 21 February 2023 - 06:49 PM.

[Simon Davis]

Hi D_Nil, i took Ana's project and added my inner join to find other occurences of Cmax in the profile, was that what you wanted?

 

  Simon.

 

Attached Thumbnails

• 

Attached Files

•  Demonstration2cmax.phxproj   902.81KB   116 downloads

Edited by Simon Davis, 22 February 2023 - 10:05 PM.