I have established a population PK model using Phoenix NLME. My dataset contains 93 subjects and follows a 2-cmpt model with an intravenous bolus input given over 5 minutes with a weekly regimen.
I am interested in calculating exposure metrics including (Cmax: post-infusion e.g. 5min; Cmin immediately pre-dose e.g. 167.99hrs and 1175.99hrs; and AUC) from:
0-168hrs (First week of exposure from the first dose). Cmax, Cmin, AUC
1008-1176hrs (Seventh week of exposure from the seventh dose onwards). Cmax, Cmin, AUC
After running the model I do get a Table of IDs, and post-hoc parameter estimates for each of the 93 patients in the model (e.g. V, V2, CL, and CL2).
How can I use the actual post-hoc PK parameter estimates in my model for the 93 subjects to estimate the exposure estimates for each subject (Cmax, Cmin, and AUC) for the First week and Seventh week, based off of the post-hoc exposure metrics I have obtained.
This would be very helpful for me as I have been unsuccessful in using PHX NLME to do this so far.
My complete PHX Project is attached. Thanks Sincerely.
Edited by csheme, 17 June 2019 - 03:40 PM.